Polyacrylamide (PAM) is a common polymer compound widely used in many fields, such as water treatment, soil improvement, oil extraction, etc. Polyacrylamide is relatively safe for general use and handling, but there are still a few things to note:

1. Toxicity: Polyacrylamide itself is stable at room temperature and non-toxic to the human body. However, during the heating process, harmful gases may be produced, so care needs to be taken to avoid high temperatures when handling polyacrylamide.

2. Allergic reactions: Some individuals may have allergic reactions to polyacrylamide, such as skin irritation, respiratory problems, etc. If you notice signs of allergy to polyacrylamide, you should stop using it immediately and consult your doctor.

3. Biodegradability: Polyacrylamide degrades relatively slowly in the natural environment. Large amounts of polyacrylamide entering natural water bodies or soil may cause potential harm to the environment. Therefore, correct handling practices should be followed when using polyacrylamide to reduce environmental impact.

Overall, polyacrylamide is relatively safe when used normally and handled correctly. However, relevant safety operating procedures should still be strictly followed during specific use, and appropriate safety assessment and management should be conducted according to the requirements of specific application fields.